Cast:

• Julianne Moore Linda Partridge
• William H. Macy Donnie Smith
• John C. Reilly Officer Jim Kurring
• Tom Cruise Frank T.J. Mackey
• Philip Baker Hall Jimmy Gator
• Philip Seymour Hoffman Phil Parma
• Jason Robards Earl Partridge
• Alfred Molina Solomon Solomon
• Melora Walters Claudia Wilson Gator
• Michael Bowen Rick Spector
• Ricky Jay Burt Ramsey / Narrator
• Jeremy Blackman Stanley Spector
• Melinda Dillon Rose Gator
• April Grace Gwenovier
• Luis Guzmán Luis
• Henry Gibson Thurston Howell
• Felicity Huffman Cynthia
• Emmanuel Johnson Dixon
• Don McManus Dr. Landon
• Eileen Ryan Mary
• Danny Wells Dick Jennings
• Orlando Jones Worm
• Michael Murphy Alan Kligman Esq.
• Pat Healy Sir Edmund William Godfrey / Young Pharmacy Kid
• Genevieve Zweig Mrs. Godfrey
• Mark Flannagan Joseph Green
• Neil Flynn Stanley Berry
• Rod McLachlan Daniel Hill
• Allan Graf Firefighter
• Patton Oswalt Delmer Darion
• Raymond 'Big Guy' Gonzales Reno Security Guard
• Brad Hunt Craig Hansen
• Jim Meskimen Forensic Scientist
• Chris O'Hara Sydney Barringer
• Clement Blake Arthur Barringer
• Frank Elmore 1958 Detective
• John Kraft Seitz 1958 Policeman
• Cory Buck Young Boy
• Tim Soronen Infomercial Guy
• Jim Ortlieb Middle Aged Guy
• Thomas Jane Young Jimmy Gator
• Holly Houston Jimmy's Showgirl
• Benjamin Niedens Little Donnie Smith
• Veronica Hart Dentist Nurse #1
• Melissa Spell Dentist Nurse #2
• James Kiriyama-Lem Dr. Lee
• Jason 'Jake' Cross Pedestrian #1
• Charlie Scott Pedestrian #2
• Juan Medrano Nurse Juan
• John Pritchett Police Captain
• Cleo King Marcie
• Michael Shamus Wiles Captain Muffy
• Jason Andrews Doc
• John S. Davies Cameraman
• Kevin Breznahan Geoff / Seminar Guy
• Miguel Pérez Avi Solomon
• David Masuda Coroner Man
• Neil Pepe Officer #1
• Lionel Mark Smith Detective
• Annette Helde Coroner Woman
• Lynne Lerner Librarian
• Scott Burkett WDKK Page #1
• Bob Brewer Richard's Dad
• Julie Brewer Richard's Mom
• Nancy Marston Julia's Mom
• Maurey Marston Julia's Dad
• Jamala Gaither WDKK P.A.
• Amy Brown WDKK Page #2
• Meagen Fay Dr. Diane
• Patricia Forte Mim
• Patrick Warren Todd Geronimo
• Virginia Pereira Pink Dot Girl
• Craig Kvinsland Brad the Bartender
• Patricia Scanlon Cocktail Waitress
• Natalie Marston Julia
• Bobby Brewer Richard
• Clark Gregg WDKK Floor Director
• Art Frankel Old Pharmacist
• Matt Gerald Officer #2
• Guillermo Melgarejo Pink Dot Guy
• Paul F. Tompkins Chad, Seduce & Destroy
• Mary Lynn Rajskub Janet, Frank's Assistant
• Jim Beaver Smiling Peanut Patron #1
• Ezra Buzzington Smiling Peanut Patron #2
• Denise Woolfork Smiling Peanut Patron #3
• New World Harmonica Trio Harmonica Players
• Robert Downey Sr. WDKK Show Director
• William Mapother WDKK Show Director's Assistant
• Larry Ballard WDKK Medic
• Brett Higgins Mackey Disciple Twin #1
• Brian Higgins Mackey Disciple Twin #2
• Michael Phillips Mackey Disciple in Middle
• Lillian Adams Donnie's Old Neighbor
• Steven Bush Paramedic #1
• Mike Massa Paramedic #2
• Dale Gibson Paramedic #3
• Scott Alan Smith E.R. Doctor
• Junichi Yanagita Mackey's Follower
• Robert Bella Detective #2
• Christina Eliason Hot Date
• Phil Hawn Bob, Seminar Attendee
• Miriam Margolyes Faye Barringer
• Tom Ohmer Detective
• Lynne Oropeza Bride
• Dayna Price Brenda Barringer
• Herb Santos Jr. 21 Dealer
• Colleen Sturtevant Gameshow Audience Member
• Tom Tangen Drunken Dart Player
• Sean Wilson Arresting Police Officer